Trafficking of T cells into tumors

CY Slaney; MH Kershaw; PK Darcy

Journal article

Trafficking of T cells into tumors

CY Slaney, MH Kershaw, PK Darcy

Cancer Research | Published : 2014

DOI: 10.1158/0008-5472.CAN-14-2458

Abstract

T cells are a crucial component of the immune response to infection and cancer. In addition to coordinating immunity in lymphoid tissue, T cells play a vital role at the disease site, which relies on their efficient and specific trafficking capabilities. The process of T-cell trafficking is highly dynamic, involving a series of distinct processes, which include rolling, adhesion, extravasation, and chemotaxis. Traf ficking of T cells to the tumor microenvironment is critical for the success of cancer immunotherapies such as adoptive cellular transfer. Although this approach has achieved some remarkable responses in patients with advanced melanoma and hematologic malignancy, the success again..

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University of Melbourne Researchers

Clare Slaney Author

Phillip Darcy Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was funded by a Program Grant from the National Health and Medical Research Council (NHMRC; #1013667). C.Y. Slaney was supported by a National Breast Cancer Fellowship (#PF-12-14). P.K. Darcy and M.H. Kershaw were supported by NHMRC Senior Research Fellowships (#1041828 and 1058388, respectively).